A Thursday night clash between the New York Giants and San Francisco 49ers kicks off Week 3 in the NFL.
The 49ers have looked like world beaters in the first two weeks, winning by a total score of 60-30 in two road games. McCaffrey leads the league in rushing with 268 yards on the ground and will get to highlight his talent in primetime for the first time this season.
The 49ers are big home favorites in the Week 3 odds, but will McCaffrey be able to continue his torrid run against the Giants stout defensive line?
We break down the Christian McCaffrey odds, the TNF odds and give our best free NFL picks, for Giants vs. 49ers on Thursday, September 21.
Don’t forget to also look at our full-game Giants vs. 49ers predictions, as well as our best TNF prop picks!